More studies will be needed to validate the results of this study, but initial findings show that D-mannose may be useful for UTI prevention. In our study, D-mannose powder had significantly reduced the risk of recurrent UTI which was no different than in Nitrofurantoin group. Patients in D-mannose group had a significantly lower risk of side effects compared to patients in Nitrofurantoin group (RR 0.276, P < 0.0001), but the clinical importance of this finding is low because Nitrofurantoin was well tolerated.
In active groups, 17.9% of patients reported side effects but they were mild and did not require stopping the prophylaxis. .dnb.com/duns-number/get-a-duns.html